By Anthony Caruso III | Publisher
We knew that this would very likely be a historic night for Denver Broncos quarterback Peyton Manning. Little did anybody expect, the game has become a blowout.
Manning broke the all-time passing touchdown record in the second quarter before halftime. Over the next two quarters, the Broncos put the game out of reach.

Nearly 10 minutes into the fourth quarter, the Broncos lead 42-10. Manning is not expected to play again tonight, as the Broncos host the San Diego Chargers on Thursday Night Football in a few nights.
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The 42 points are the most scored through three quarters against the 49ers over the past 4 seasons under head coach Jim Harbaugh. In fact, at the moment, Harbaugh’s worst loss with the team came on December 23rd, 2012 against the Seattle Seahawks at CenturyLink Field, when the 49ers lost 42-13.
The two are also tied together in Indianapolis Colts history, as Harbaugh was the last quarterback in their franchise history to throw a touchdown before Manning arrived. Marvin Harrison, now retired, was lucky to catch Harbaugh’s last and Manning’s first.
Manning has thrown his 11th game with 4 touchdown passes since the beginning of the 2013 season. No other quarterback has been able to 5 such games during this time.
The Broncos signal-caller has 33 career games with 4 touchdown passes in a game. Drew Brees, the quarterback of the New Orleans Saints, is second with 25.
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Manning went 22 of 26 for 318 yards. He had four touchdown passes.
The legendary quarterback hit Demaryius Thomas for a 40-yard touchdown reception. Manning also hit Thomas for an eight-yard touchdown reception.
The future Hall of Famer hit Wes Welker for a 39-yard touchdown reception. He also hit Emmanuel Sanders for a three-yard touchdown reception.
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